While installing Apache 2.2.21 in /usr/local/www/apache22, an error "/usr/local/build-1/libtool: not found" occurred.

You just need deinstall apr1, and reinstall apache22 again.

#pkgdb -F; portsclean -CDD; portsnap fetch update

# cd /usr/ports/devel/apr1
# make deinstall clean

# cd /usr/ports/www/apache22
# make install clean